Insulite Laboratories
Systems That Restore Health
March 2008

Dr. Robert Buynak

Dr. Robert Buynak of Insulite Laboratories' Medical and Advisory Team is Clinical Instructor of Medicine at Indiana University School of Medicine and practices internal medicine in Valparaiso. Additionally, he is a Clinical Research Physician/Principal Investigator for American Medical Research, Inc. in Oak Brook, IL. A graduate of Harvard Medical School, Dr. Buynak completed his Internship and Residency at the Mayo Clinic in Rochester, MN. He is the author of several books including Dr. Buynak's 1-2-3 Diabetes Diet: A Proven Approach to Weight Loss Without the Gimmicks or Risks.

Welcome to the 48th edition of Viewpoints, our monthly e-newsletter. Click on In This Issue headlines to read individual articles.


 Close-up of mature adult male with mustache.
Scientists believe they have found the key to understanding how Alzheimer's Disease causes profound memory loss.

The normal process of forgetting constantly 'cleans up' our memories by culling inconsequential information from our brains.

Now, researchers at the Buck Institute for Age Research in Novato, California, believe that the brain becomes stuck in this process of removing memories in sufferers from Alzheimer's, which has been linked to Insulin Resistance.

"Young brains operate like Ferraris – shifting between forward and reverse, making and breaking memories with a facility that surpasses that of older brains, which are less plastic," said lead researcher Dr. Dale Bredesen.

"We believe that in aging brains, Alzheimer's occurs when the 'molecular shifting switch' gets stuck in the reverse position, throwing the balance of making and breaking memories seriously off kilter."

Researchers were first alerted to this phenomenon after studying the splitting of one molecule called amyloid precursor protein (APP) in human brain tissue.

They found those suffering from Alzheimer's Disease showed a higher rate of this splitting process than people of the same age who did not have the disease.

Alzheimer's is the most common form of dementia, where healthy brain tissue degenerates, causing a decline in memory and mental abilities.

It has been linked to impaired blood flow to the brain resulting from excess weight and obesity, which often have the glucose and insulin imbalance called Insulin Resistance as their underlying cause.

Latest findings suggest 10 million "baby boomers," or 1 in 8, will succumb to Alzheimer's over the coming years.
 Woman holding her hands on her chest.
A threefold increase in strokes among middle-aged American women in recent years is being blamed by doctors on the obesity epidemic in the U.S.

Nearly 2% of women aged 35 to 54 reported suffering a stroke in the most recent federal health survey, from 1999 to 2004. Only about 0.5% reported a stroke in the previous survey, from 1988 to 1994.

The percentage increase is small because most strokes occur in older people. But the sudden spike in middle age and the reasons behind it are viewed as ominous.

One reason is because the increase happened even though more women in the recent survey were on medicines to control their cholesterol and blood pressure – steps that lower the risk of stroke.

But women's waistlines are nearly two inches bigger than they were a decade earlier and that bulge corresponds with the increase in strokes, say researchers.

Women in the survey had an average BMI (Body Mass Index) that had risen from 27 to 29 between surveys. A BMI of 30 and over is regarded as obese. Women also now have higher blood sugar levels.

No other traditional risk factor like smoking, heart disease or Diabetes changed enough between the two surveys to account for the increase in strokes.

The study was led by Dr. Amytis Towfighi, a neurology specialist at the University of Southern California in Los Angeles, who used the National Health and Nutrition Surveys -a federally-funded project that gives periodic health checkups and questionnaires to a wide sample of Americans.

Participants are routinely asked whether a doctor had ever told them they had suffered a stroke.

Researchers saw that the stroke rate had spiked in middle-aged women but stayed about the same, at around 1%, in middle-aged men.

Belly fat stood out as the main reason for the increase in females, Dr. Towfighi said. The portion of women with abdominal obesity rose from 47% in the earlier survey to 59% in the recent one.

The change in men was smaller and previous studies have shown that "abdominal obesity is a stronger risk factor for women than men," she added.

Men traditionally have had a greater risk of stroke than women, and women start catching up to men five or 10 years after menopause.

But the new research suggests a need to re-evaluate the incidence of stroke in women, say doctors, because they may now be more at risk in middle-age than men.
 Dr. Sari Cohen
Dr. Sari Cohen
of Our Medical
& Advisory Team
It certainly makes sense to evaluate both partners when a couple has difficult conceiving a child.

According to the National Institutes of Health, male infertility accounts for approximately 40% of infertility in couples.

The underlying cause of the man's infertility can stem from a variety of reasons. But recent research confirms that being overweight or obese can alter male fertility by affecting hormone levels and sperm health.

A February 2008 article in the journal Fertility and Sterility noted a correlation with obesity and decreased testosterone levels. The authors also reported a decrease in inhibin B levels in overweight men. (1) Inhibin B correlates with sperm motility – the ability of the sperm to swim forward in the vagina.

Another article in the January issue of Fertility and Sterility concluded that male obesity was correlated with low sperm concentration and decreased sperm motility. (2) These problems were greater with increasing BMI (Body Mass Index).

Other studies have come to similar conclusions. (3) Interestingly, a Danish study published in 2004 reported that BMI's that are either too high and too low could lead to reduced sperm quality. (4)

In order to increase your and your partner's chances for conception, the first step may be to embark on a healthy plan for weight reduction involving a balanced, nutritious diet and a regular exercise.

(1) Pauli EM et al. Diminished paternity and gonadal function with increasing obesity in men. Fertil Steril. 2008 Feb 19 [Epub ahead of print] PMID: 18291378.

(2) Hammoud AO et al. Male obesity and alteration in sperm parameters. Fertil Steril. 2008 Jan 4 [Epub ahead of print] PMID: 18178190.

(3) Kort HI et al. Impact of body mass index values on sperm quantity and quality. J Androl. 2006 May-Jun;27(3):450-2. Epub 2005 Dec 8. Sallmen M. et al. Reduced fertility among overweight and obese men. Epidemiology. 2006 Sep;17(5):520-3. PMID: 16339454

(4) Jensen TK et al. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertil Steril. 2004 Oct;82(4):863-70, PMID: 15482761
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 Couple with bikes.
Don't bother searching for the fountain of youth because the secret of staying young for your age may be much more accessible than you think.

Something as simple as keeping active may be the key because exercise can apparently slow your biological clock.

According to a new study of twins, people who exercise are up to nine years biologically younger than those who do not. The study of 2,401 twins found that a sedentary lifestyle not only raises the risk of a range of disorders like heart disease and some forms of cancer but it also appears to play a crucial role in the aging process.

You may never have heard of them. But it appears to all boil down to the length of structures called telomeres, which protect the DNA on the chromosomes.

Many studies have shown telomeres get shorter over time, suggesting the cells are aging or dying. But when researchers from King's College, London, extracted DNA samples from their volunteers, they found people who exercised more each week had longer telomeres.

Individuals who worked up a sweat 3 hours each week had longer telomeres and were biologically 9 years younger than people who did under 15 minutes a week.

Even moderate exercise for one-and-a half-hours each week provided a four-year "youth" advantage.

Studying twins provided a unique opportunity to gauge the effects of exercise on people with the same or similar genetic make-up and backgrounds but with different activity regimes.
Insulite Laboratories Systems
This is the time of year when many people's minds are focused on tax matters.

So, if you don't already know it, perhaps you'll interested in learning that dietary supplements can be claimed as a health care tax deduction IF they are "recommended by a medical practitioner as treatment for a specific medical condition diagnosed by a physician."

A lot of people miss out on this tax break, which only applies to those whose deductions exceed the standard deduction amount.

But it can really add up if a person is using nutraceuticals. If you're on one of the Insulite systems, it might be worth your while mentioning it to your tax professional.

Quick Links
"I have been on the Insulite Pre-Diabetes System for one year. Within that year, I have lost 76 pounds and my glucose level has improved.

"I followed the plan provided and have also become physically fit. I am able to exercise 2+ hours a day and hike difficult treks at the parks without fatigue.

"I feel better and healthier than I have in a very long time. I wish to tell others what a wonderful system this is.

"I have ordered another year of the Pre-Diabetes System and expect that the improvements will keep coming."

Austin, Texas
Have You Been Diagnosed with Pre-Diabetes?

If You Have, We're Here to Help You Restore Your Health

Insulite Laboratories is committed to giving you a better understanding of Pre-Diabetes and a common underlying cause of the condition, namely Insulin Resistance-linked excess weight or obesity.

The Insulite Pre-Diabetes System has been scientifically-formulated to help reverse Insulin Resistance, an imbalance of blood glucose and insulin.

Pre-Diabetes is a reversible condition that is diagnosed when blood sugar and insulin levels are higher than normal but not high enough for Type 2 Diabetes. If neglected, however, Pre-Diabetes can lead to Type 2 Diabetes.

This latter disorder can only be managed for the rest of a Diabetic's life in the vast majority of cases and may require daily injections of insulin. Type 2 Diabetes, itself, is a severely increased risk factor for blindness, heart and kidney disease and the need for amputation.

The Insulite Pre-Diabetes System includes a scientifically-designed combination of nutrients which are primarily designed to increase insulin sensitivity, which can, in turn, prevent the onset of Type 2 Diabetes.

With this system, cells can absorb blood glucose more efficiently for conversion to energy, thereby reducing levels of circulating glucose. A decrease in elevated blood glucose lowers the secretion of insulin.

And when insulin and glucose are in balance, weight loss is facilitated and the symptoms of a related disease like Pre-Diabetes can be reversed.