Insulite Labs
March 2005 
IN THIS ISSUE: Insulite Laboritories

Welcome to twelfth edition of Viewpoints, our monthly e-newsletter.

How time flies! Almost a year has passed since the first edition of Viewpoints and, to judge by the positive feedback from our ever-growing number of readers, we seem to have struck a popular balance in the articles we’ve featured so far.

Supporting our clients in achieving their goal of a new sense of well being is a crucial element of the Insulite System, together with other factors like healthy exercise and a nutritious diet enhanced by neutraceutical supplements. We want the newsletter to play its part by informing readers about new scientific discoveries regarding the benefits of weight loss and the most helpful ways of achieving them. You can’t be too well-informed about health issues these days and we place a strong emphasis on passing along up-to-the minute data.

But everything doesn’t have to be serious, of course, and you can have fun while you transform your health. That’s one of the aims of our Insulite Lifestyle section, which this month shows how the small dishes called tapas and meze can pack a deliciously big taste. Happy nibbling!

“Start by doing what’s necessary, then what’s possible and, suddenly,
you are doing the impossible.”

- St Francis of Assisi

Who knows what you can achieve if you put your mind to it?
Start By Doing What's Necessary


Intelligence Report


Overweight and obese men run a double risk of developing prostate cancer, according to two new studies.

In the first, the Research Institute of Public Health at the University of Kuopio, Finland, recently published a report on the increased risk of prostate cancer in middle-aged men suffering from Metabolic Syndrome, a condition characterized by excess weight or obesity. Known also as Syndrome X, Metabolic Syndrome has until now been seen primarily as a collection of risk factors that substantially increase the chance of developing Cardiovascular Disease and Type II Diabetes.

Participants in the Finnish study were 1,880 men from the eastern part of the Scandinavian country who did not have a history of cancer or Type 2 Diabetes. Metabolic Syndrome was diagnosed in 357 of the men at the start of the study. Over a period of 13 years, a total of 183 cancers occurred in the group as a whole, of which 56 were cancer of the prostate.

Almost twice as many men with Metabolic Syndrome developed prostate cancer as men without the syndrome, after adjustment for age, alcohol consumption and physical fitness. The study showed that overweight and obese men with Metabolic Syndrome ran a more than 70% greater risk of developing prostate cancer than leaner men.

Researchers concluded that the incidence of prostate cancer may be reduced by curbing the current worldwide epidemic of overweight and obese middle-aged men who have developed Metabolic Syndrome because of sedentary lifestyles.

Many people are unaware that they are suffering from Metabolic Syndrome, even though the American Heart Association estimates that 20-25% of the adult population of the U.S. have this disorder – between 58 and 73 million men and women.

Metabolic Syndrome is characterized by having at least three of the following symptoms:
  • Insulin Resistance (when the body can’t absorb blood sugar or insulin properly)
  • Abdominal fat – in men this means a 40 inch waist or larger, in women 35 inches or larger
  • High blood sugar levels – at least 110 milligrams per deciliter (mg/dL) after fasting
  • High triglycerides – at least 150 mg/dL in the blood stream
  • Low HDL (the “good” cholesterol) – less than 40 mg/dL
  • Prothrombotic state (a precursor of Cardiovascular Disease)
  • Blood pressure of 130/85 mmHg or higher
A second study suggests a man’s weight may “mask” the accuracy of a common test to detect prostate cancer, with researchers warning that doctors could be missing this dangerous cancer in obese men.

Between the years 2001-04, a team at San Antonio’s University of Texas Health Science Center studied 2,799 men who were free of prostate cancer. In results released online in the journal Cancer, researchers reported finding that the more obese men were, the lower their levels of prostate-specific antigen or PSA. A man’s PSA of 4.0 or lower usually means no cancer and the study results were surprising because prostate cancer has been shown in previous studies to be more aggressive in obese men than males of average weight. The Texas researchers wanted to discover whether the detection of cancer was somehow being delayed in obese men.

The study found that obese men have PSA levels that are about 30% lower than males of normal weight. “That tells us it’s likely or it’s possible that prostate cancer detection may be delayed in overweight or obese men,” said Jacques Baillergeon, associate professor of epidemiology at the University of Texas Health Science Center.

The study did not explain why obese men have lower PSA levels. But doctors believe obese men produce more estrogen, which drives down testosterone levels and could affect the antigen used in the PSA test.

The research may spur many doctors to take a closer look at the test results of obese male patients. “For sure, I will be more vigilant in my patients, who are obese, in evaluating their PSA,” said Dr. Nelson Stone of Mount Sinai School of Medicine in New York City, who was not involved in the study.

Dr Stone added that colleagues might be losing some of the PSA test’s sensitivity, reducing its ability to detect prostate cancer in obese patients. “We may have to set our sights lower,” he said.

The antigen used in the PSA test is made by normal prostate cells and is measured in blood. The higher the antigen level, the more likely the chance of prostate cancer, according to the American Cancer Society. But having a high PSA level is not a definitive diagnosis of cancer, which is why the Atlanta-based Society recommends that men with high PSA levels should have a biopsy.

The Texas study builds on previous research released in May last year in the New England Journal of Medicine which found that 15% of men with a “normal” PSA actually had prostate cancer and that two-thirds of those men had aggressive cases.



Regain Lost Memory


Reducing blood sugar levels can lead to improved memory for people suffering from Type 2 Diabetes.

Insulin Resistance, a disorder that creates unbalanced levels of glucose and insulin in the blood stream, is a root cause of Pre-Diabetes, which, if untreated, can lead to Type 2 Diabetes. While previous research has shown that managing blood sugar levels can have benefits in such areas as kidney function and sight for Diabetics, a new study by the University of Pittsburgh School of Medicine is the first to extend the effect to cognitive function.

There are 17 million people suffering from Type 2 Diabetes in the U.S. today and they are up to twice as likely as the general population to experience cognitive decline. Even mild cognitive impairment can have a negative effect on memory. One result is that some people have difficulty learning new information and remembering that information. Cognitive decline can also have an impact on a person’s ability to perform routine tasks.

The Pittsburgh study set out to determine whether there was a relationship between blood sugar control and cognitive function in people with Type II Diabetes. Researchers recruited 141 individuals, who, other than having been diagnosed with Type 2 Diabetes, were relatively healthy. The average age of the participants was 60.

To help balance blood sugar levels for the purposes of the study, all of the participants took the drug metformin and were then given random doses of either Avandia or glyburide. Fasting blood sugar was measured at the beginning of the 24-week trial and all individuals took a preliminary series of psychological tests to ascertain cognitive function. Three categories of function were assessed: learning ability, cognitive efficiency and working memory.

The main result was that balancing blood glucose levels had no effect on learning ability or cognitive efficiency but it did show a significant improvement over the 24 weeks in working memory. In one of the major memory tests, there was a 30% improvement.

In both groups, working memory improvements correlated with improved control of blood sugar. Individuals with the biggest improvement in control had the greatest improvement in working memory. Those who took Avandia for the study had fewer side effects.


“Our brains are affected by blood sugar highs and lows.”

This recent research reaffirms what we at Insuilte Laboratories believe is true. Imbalances in blood sugar levels caused by consuming refined carbohydrates have an impact on nearly every system in our bodies. These findings further confirm what dietary influences in children of school age have shown-- those having highly refined carbohydrate breakfasts do poorer on tests and demonstrate poorer learning ability. We know that our brains are affected by blood sugar highs and lows when we experience irritability, headaches and shakiness during a low blood sugar moment. At the same time we know that we feel more stable, physically and emotionally, with a balanced diet of good fats such as avocados, nuts, eggs and sufficient protein at each meal.

Dr. Mary Shackelton, MPH ND, is the Medical Director of Insulite Laboratories.

  Obese people are not compulsive overeaters
Myth: Obese people are compulsive overeaters.

Fact: The compulsive eater, whether thin or obese, is a person with an eating disorder. Simply being obese does not indicate the presence of an eating disorder. Many people who suffer from obesity eat far less than most would realize. Their obesity is due to a complex number of factors including genetics, metabolism and dieting history and, most importantly, being insensitive to their own insulin. Once the body has stopped responding properly to the messages of insulin, food that should be used as fuel for the cells is instead stored as fat at an increasing rate. So when you see someone who is struggling with obesity, you should know that they have metabolic challenges that cause this disorder.

Dr Mary Shackelton - Medical Director for Insulite Laboratories
Q. What is the connection between insulin and high blood pressure?

A. Anytime there is an elevation in glucose in the blood stream, such as eating a carbohydrate-rich meal, there is a compensatory rise in insulin secretion from the pancreas. Over time, and after consistently elevated carb consumption, excess insulin becomes a constant in the blood stream. This condition is known as hyperinsuliemia, which, in turn, causes high blood pressure, also known as hypertension.

This latter condition is major health problem for several reasons - it’s very common, its consequences are widespread and it remains relatively silent and undiagnosed until late in its course of causing cardiovascular damage.

Hypertension is one of the most important risk factors in both coronary heart disease and stroke. It can also lead to congestive heart failure, aortic dissection (a hole in the aorta) and kidney failure.

Blood pressure is determined by cardiac output, or how much blood the heart pumps per beat, and total peripheral resistance, which is a measure of how easily the blood is pumped to the distant organs of the body.

Excess insulin is an underlying factor in high blood pressure because it can cause atherosclerosis. This condition is a build-up of harmful material called plaque which narrows the inside width of arteries and reduces the easy flow of blood. Additionally, excess insulin damages the inside lining of the blood vessels which decreases it's elasticity. A decrease in elasticity causes the heart to work harder to pump the blood through the entire cardiovascular system.

Visit our website to learn about the new Insulite PCOS System.

“Thank you for being so informative, I’m always amazed about the little-known facts you make available. I’m doing my best to lose weight and live a much healthier life.”

- Linda Anderson,
  Houston, TX

Insulite Laboratories would like to share other experiences like this one to inspire our many clients on the same path. Tell us your story and we will use it in a future issue of this newsletter, as well as on web sites and affiliate sites.

If you are uncomfortable with us publishing your name, we are quite happy to use your initials to preserve your anonymity. Please email us at

Temper May Affect your child's Weight TEMPER MAY AFFECT
Youngsters who throw temper tantrums could be at risk of becoming overweight. A new study by Stanford University shows that the risk increases if their parents are also heavier than they should be.

Dr. W. Stewart Agras, leader of the study, says one reason may be because the parents of difficult children try to placate them with food. But the parents may also try to put too many limits on their child’s eating habits.

“Our own theory,” said Dr.Agras, “is that parents may find these children difficult and may over-control their feeding and not allow the child to moderate his own feeding ... so he doesn’t learn to handle food normally.”

The percentage of children in the U.S. who are considered severely overweight has doubled in the last 20 years to 15%. The majority of these kids will carry the extra weight into adulthood, setting themselves up for a wide range of health problems, including Insulin Resistance-related obesity which can lead to Type 2 Diabetes, Polycystic Ovarian Syndrome (PCOS) and the cluster of cardiovascular disorders known as Metabolic Syndrome.

Dr. Agras’ study followed 150 children born at three San Francisco Bay Area hospitals for an average of 9 1/2 years to come up with the results published in the Journal of Pediatrics. Researchers have long known that overweight parents are more likely to have overweight kids. But this new study found that the correlation was exacerbated if the child had a difficult temperament.

Another finding was that overweight children need less sleep than normal-sized kids, leading researchers to conclude that the explanation may be that the former were less tired because they were less active.
Your children's HealthIf you are concerned that your child may be on the path to becoming obese, begin to watch how food is used in your family. Are you using food as a positive reinforcer? In other words, do you reward good behavior with food and do you take "treats" away for bad behavior? One suggestion for avoiding this common and tempting pattern is to agree upon a reward that is non-food related such as a new coloring book, a play date at a friend's house, play time at the park or time alone with just one parent for "special attention".

Try to reinforce healthy food choices that your child may make without rewarding them with a dessert, even though it is tempting to offer dessert for a "clean dinner plate".

It is not uncommon for adults or children to "self-medicate" with food. The link between carbohydrate consumption and depression (which can manifest itself as aggression, anger and tantrums) is clear-- the more carbohydrates we consume the more serotonin we produce. Serotonin is a neurotransmitter that has a calming effect on brain chemistry. People who struggle with depression often have less serotonin than they need, which is why constant carbohydrate craving and the satisfaction that one feels when eating carbohydrates is such a difficult cycle to break.

Most importantly, try to have time each day with your children to just talk and let this be over a meal. Mealtime is an important way to bond as a family. If you set aside this time together to air your concerns, joys and problems, kids will begin to open up and discuss their feelings, rather than acting out or withdrawing.

Use your Imagination
“The highest kite you can fly is imagination.”
  - Lauren Bacall
Don’t allow your outlook to be limited...


Tapas and mezeTwo of the hottest trends in dining, tapas and meze, might seem like they were devised for today’s diet-conscious world. But these deliciously healthy Spanish and Greek ways of eating small samples of food have been around for centuries.

The origin of tapas depends on which story you believe. Some say King Alfonso the Wise of Spain dreamed up the idea after illness forced him to maintain his strength by taking small bites of food with wine between meals. Other will tell you it was originated by Spanish farmers during long, grueling days in the fields when they needed bites of food to keep going until it was time for a main meal.

Meze, on the other hand, comes from a leisurely Greek tradition of friends enjoying sunny, mid-afternoon sessions of nibbling snacks, talking and drinking the odd glass of wine or ouzo.

In the beginning, both tapas and meze were meant to tease the palate, rather like appetizers. But these days they have replaced entrees at a growing number of restaurants in America and become a main course for people watching their weight. One thing hasn’t changed, however. They are still meant to be sociable meals, ideal for sharing with friends while chatting over a glass of wine.

The treats on offer can range from everything from small portions of simple steamed mussels and habas con chorizo (fava beans with sausage) to taramasalta (a codfish roe spread) and tyropitakia (warm, buttery feta cheese pies). Other dishes can include colorful salads, skewered meats, seafood, nuts and olives.

The health benefits are excellent if eaten in moderation. Small meals are regarded as being easier to digest and, thanks to being prepared with liberal quantities of olive oil, these dishes are packed with Vitamin E and beneficial fats.

Three tips for trying tapas and meze:
  • Don’t be fooled by the size of these dishes and order ten different offerings. Start with two or three and see how it goes as you share them with your friends and sample their choices, too. You can always order more.
  • Go out to eat with as many friends as you can muster. That way, you get to try more delicious tastes.
  • Start off being hungry and by the time you finish you’ll have a feeling of satisfaction from a variety of food without having played havoc with your diet.

CoQ10 anti-oxidantGood health is made up of many elements. Nutrients are essential and CoQ10 is one of the most important for energy.

While it may sound like an ingredient of a secret formula for rocket fuel,  CoQ10 is actually an anti-oxidant nutrient in each cell of the body. It was first identified by researchers in Wisconsin in 1957.

The nutrient is found in fish and meat, among other foods, and plays a significant role in the energy system of cells. Although humans make some of their own CoQ10, there are significant benefits to be derived from taking supplements of this antioxidant.

Research shows that CoQ10 is beneficial in the treatment of Cardiovascular Disease, including heart failure and high blood pressure (hypertension) The nutrient is particularly effective at increasing energy production in the heart muscle. It has also been evaluated as important for treating Type II Diabetes and lowering high levels of LDL "bad" cholesterol.

Insulin resistance often causes elevated cholesterol levels and many of our clients take medications to lower their cholesterol. One class of cholesterol-lowering drugs -statin- inhibits the body's manufacture of CoQ10. Supplementing CoQ10 daily at a minimum of 50 mg per day can help prevent the depletion that these medications may cause.


Insulite Laboratories is Here for You
You are well on the way to reversing your Insulin Resistance and preventing its related conditions such as PCOS (Polycystic Ovarian Syndrome), Metabolic Syndrome (Syndrome X) and Pre-Diabetes. You are also taking important steps to achieving your desired weight loss goal and the healthy lifestyle you deserve.

Remember that persistence is crucial.

We at Insulite Laboratories are committed to your success and your well being. We're here to help you.

Please contact us with any questions or to order the Insulite System or the Insulite PCOS System at

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DISCLAIMER: The information contained in this newsletter is for the sole purpose of being informative. This information is not and should not be used or relied upon as medical advice. Always seek the advice of your physician, nurse or other qualified health care provider before you undergo any treatment, take any medication, supplements or other nutritional support, or for answers to any questions you may have regarding a medical condition.

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