Dr. Andrea Lee
of Our Medical
& Advisory Team
Welcome to the 45th edition of Viewpoints, our monthly e-newsletter. Click on In This Issue headlines to read individual articles.
|INTELLIGENCE REPORT: LOW-CARB DIET CURTAILS METABOLIC SYDROME INFLAMMATION RISK
New dietary advice could reduce the dangerous symptoms of Metabolic Syndrome (Syndrome X), - the condition afflicting up to 33% of adult men and women in the U.S. which increases the risk of heart disease, Diabetes and other serious illnesses.
People with Metabolic Syndrome have long been advised to eat a weight-reducing, low-fat diet with resulting high-carbohydrate intake, even though a low-carb regime has been found to be more effective at reducing classic symptoms of the disorder like high triglycerides.
But a new study indicates that a diet low in carbohydrates is also more effective than a low-fat diet when it comes to lowering saturated fatty acids in the blood and reducing inflammation, which can damage arteries and lead to cardiovascular disease.
While there have been contradictory and confusing messages directed at health conscious consumers about dietary recommendations in the past, most researchers agree on the need to limit inflammatory agents.
The new report, published in the on-line version of the journal Lipids, shows much greater improvement in inflammatory markers in patients with Metabolic Syndrome on a very low carbohydrate approach compared to a low-fat diet. (1)
Lead researcher Professor Jeff S. Volek, of SUNY Downstate Medical Center in Brooklyn, New York City, described the study as "adding to the evolving picture of improvement in general health beyond simple weight loss in keeping blood glucose and insulin under control."
The current work concludes that "lowering total and saturated fat only had a small effect on circulating inflammatory markers, whereas reducing carbohydrates led to considerably greater reductions in a number of pro-inflammatory cytokines, chemokines and adhesion molecules.
Fellow researcher and biochemistry professor Richard Feinman added: "The inflammation results open a new aspect of the problem. From a practical standpoint, continued demonstrations that carbohydrate restriction is more beneficial than low fat could be good news to those wishing to forestall or manage the diseases associated with Metabolic Syndrome."
One of the remarkable effects in the data is that despite the three-fold greater saturated fat in the diet for the low-carb group, saturated fat in the blood turned out to be higher in the low-fat group due to the process known as carbohydrate-induced lipogenesis.
Professor Volek pointed out that "this clearly shows the limitations of the idea that 'you are what you eat.' Metabolism plays a big role. You are what your body does with what you eat."
(1) Suny Downstate Medical Center (2007, December 4). Low-carb Diet Reduces Inflammation And Blood Saturated Fat In Metabolic Syndrome.
ScienceDaily. Retrieved December 10, 2007.
|NEW RESEARCH: SCIENTISTS CRACK CODE OF BREAST CANCER GENE LINKED TO WEIGHT GAIN
Scientists have discovered how a single faulty gene linked to weight causes one of the most aggressive types of breast cancer.
The breakthrough could offer hope to millions of women by paving the way for better treatments for basal-like breast cancer tumors. These are the most dangerous and hardest-to-treat forms of the disease.
For more than a decade, medical science has known that mutations in a gene called BRCA1 put women at much higher risk of developing aggressive "basal type" breast cancer. These tumors grow fast, spread quickly and do not respond well to conventional drugs.
The risks are so high that some women with the BRCA1 mutations opt to have their breasts removed, rather than take a chance on getting cancer.
Women who carry mutated forms of genes BRCA1 and BRCA2 account for at least 5% of breast cancer cases in the U.S. They are also at greater risk of developing ovarian cancer.
Studies have shown, however, that women between 18 and 30 with BRCA1 and 2 mutations can significantly reduce their risk of developing breast cancer by losing weight.
Women who lost at least 10lbs between those ages reduced the risk by 65%. But females in that age group who gained the same amount of weight increased their risk of breast cancer by 44% by the age of 40.
The BRCA1 mutations, inherited from parents, are carried by one woman in 800. However, the reason why the BRCA1 gene is linked to cancer has been a mystery ... until now.
In a paper published in the science journal Nature Genetics, scientists have shown that a faulty BRCA1 gene triggers cancer by disabling another vital gene, called PTEN - one of the body's "tumor suppressor" genes, which ensures cells do not grow uncontrollably.
Normally, the BRCA1 gene helps repair any mistakes that crop up in PTEN. But if BRCA1 goes wrong, any faults in the PTEN gene remain unrepaired. Without its guiding hand, cells proliferate and form tumors.
"These findings are exciting because ever since the link was established between BRCA1 and breast cancer more than ten years ago, we have been frustrated by our lack of understanding about how mutations in this gene cause breast cancer," said researcher Dr Ramon Parsons, of New York's Columbia University.
"We have been stymied by our limited resources to treat these cancers, which are associated with very poor prognoses. Now that we know that PTEN is involved, we finally have a target for therapy for these cancers."
A fault in BRCA1 "is like cutting the brake cable on a car," he added.
The research team made the link by searching for faulty DNA in 34 biopsies from women with BRCA1 tumors. The PTEN had been damaged and inadequately repaired in about two-thirds of the cancers.
Researchers estimate that around half of all BRCA1 cancers are started by unrepaired damage to PTEN.
|CONSULT DR. SARI: "WILL MY YOUNG DAUGHTER INHERIT MY PCOS?"|
Dr. Sari Cohen
of Our Medical
& Advisory Team
There does seem to be a hereditary component to Polycystic Ovarian Syndrome (PCOS) but this is not proven. In other words, there isn't a 'PCOS gene.'
The tendency to develop PCOS may be inherited from the mother's side, the father's side or both. But just because your daughter may have a predisposition for PCOS does not mean she will definitely develop the condition because there are many lifestyle modifications that can prevent its development.
It was previously thought that PCOS could not be diagnosed until adolescence when girls with PCOS would develop traits that are typically considered to be masculine, such as excess hair growth and acne.
But recent research published in the Journal of Clinical Endocrinology and Metabolism shows that earlier signs of PCOS may be detectable before the onset of these hyperandrogenic symptoms. (1)
The researchers examined both pre-pubertal and pubertal daughters of women with PCOS and compared them to daughters of women without PCOS.
They established that certain metabolic abnormalities, such as high insulin levels, existed only in the daughters of women with PCOS. This means that even before parents and doctors can detect outward signs and symptoms of PCOS, it may be possible to detect early risks for PCOS and therefore start prevention and treatment before the disease develops fully.
PCOS is closely associated with obesity and Insulin Resistance. Encouraging your family to eat a healthy diet and exercise regularly can help prevent weight problems and the onset of PCOS.
(1) Sir-Petermann T. et al. Early Metabolic Derangements in Daughters of Women With Polycystic Ovary Syndrome (PCOS).
J Clin Endocrinol
Metab. 2007 Sep 11 [Epub ahead of print] PMID: 17848407.
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|INSULITE LIFESTYLE TIPS: COPING WITH HOLIDAY STRESS
There's so much to do during the holiday period that it can be tough on your nerves. So here are a few quick and simple fixes for stress.
While performing these exercises, inhale through the nose and exhale through the mouth. Don't try these exercises, however, if you have any doubts about your fitness or ability to perform them.
1) Relax Your Body - lie on your back with your feet hip-distance apart and your palms facing up. Relax your body from the top down, bit by bit, by pretending to let yourself sink into the floor. Breathe slowly from the abdomen, bringing air in through the nose and out through the mouth. Stay in this position for 3 minutes.
2) Shoulder Release - keeping your hands on the floor, sit back, bringing your rear to your heels. Lay your upper body over your thighs and place your forehead on the floor. Place your hands, palm up, by your feet. Let your shoulders release around your knees. Hold for 30 seconds.
3) Upper Body Stretch - Extend your arms along your sides and rest your forehead on the floor. Interlace your fingers behind your back. Inhale as you pull your shoulder blades together and lift your chest briefly off the floor. Keep your eyes focused on the floor. Exhale as you lower yourself. Repeat several times if you feel comfortable.
4) Hamstring Stretch - seated on the floor, bring both legs to your chest and then set one foot on the floor. Extend the other leg up from the hip. Put your hands behind your thigh or reach up and grab your calf. Exhale gentle as you pull in the leg a little closer. Hold for 30 seconds and then repeat on the other side.
5) Rolling Stretch - bend your knees and pull both legs into your chest. Wrap your arms around your calves. Think that you are lengthening your spine and exhale as you lower your back into the floor. Hold for 30 seconds.
HAPPY, HEALTHY HOLIDAYS TO YOU ALL
FROM INSULITE LABORATORIES
A MONTHLY MESSAGE FROM INSULITE LABORATORIES
More evidence is emerging all the time that Type 2 Diabetes can cause a wide variety of ghastly complications.
A link is already strongly established between Diabetes and cardiovascular and kidney disease, blindness and the need for amputation.
Now hearing loss has been added to the list after the discovery by a recent survey that deafness is more common in Diabetics than people without the condition.
The news comes as another report suggests that blindness cases caused by Diabetes-linked nerve damage could triple from 5.8 million in 2005 to 17.7 by 2050.
A balanced, nutritious diet tied to regular exercise to achieve weight loss can greatly improve a Type 2 Diabetic's chances of avoiding all these complications.
And adopting a similar healthy lifestyle can help manage or reverse the symptoms of Pre-Diabetes - the condition in which blood sugar and insulin are higher than normal but not elevated enough for a diagnosis of Type 2.
As a result, the onset of full-blown Diabetes can be prevented.
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more than three weeks in a row.
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Its nice to have my blood sugars under control
because it makes my life better in so many ways.
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missing out on certain foods because I know what I am eating now - and will
continue to eat for the rest of my life - is what is making me feel better,
along with the Insulite supplements. I have lost 15 pounds and I know the rest of
the weight I want to lose will come off in time.
"Thank you to all of you who made these supplements available to the
public so we could get our lives back, feel better and be healthier."
Walnut Creek, CA
Have You Been Diagnosed with PCOS?|
If You Have, We're Here to Help You Restore Your Health
Insulite Laboratories is committed to giving you a better understanding of Polycystic Ovarian Syndrome (PCOS) and a common underlying cause of the condition, namely Insulin Resistance-linked excess weight or obesity.
So we are very pleased to offer the Insulite PCOS System, which has been scientifically-formulated to help reverse Insulin Resistance, an imbalance of blood glucose and insulin.
PCOS is a major cause of female infertility, as well as irregular periods and excessive bleeding, obesity, skin conditions like acne and brown patches, excess body hair, female baldness and reduced sex drive.
The Insulite PCOS System includes a scientifically-designed combination of nutrients which are primarily designed to increase insulin sensitivity.
As a result, cells can absorb blood glucose more efficiently for conversion to energy, thereby reducing levels of circulating glucose. A decrease in elevated blood glucose lowers the secretion of insulin.
When insulin and glucose are in balance, weight loss is facilitated and a related disease like PCOS can be reversed.