Insulite Labs
December 2005
IN THIS ISSUE: Insulite Laboritories

Welcome to the twenty-first edition of Viewpoints, our monthly e-newsletter.

We at Insulite Laboratories know how just difficult the holiday season can be to stick to your plan to lose weight and enjoy better health. There are temptations everywhere you turn, so it's no wonder that the average person gains 5 lbs between Thanksgiving and New Year's Day.

But you can avoid a similar fate by following some simple tips to keep trim while still enjoying all the festive fun.

The Lifestyle section in this month's edition shows the health benefits that red wine can offer. But always remember to drink moderately. Keep track of how much you are actually consuming by refusing a top-up before you've finished your drink. Alcohol not only stimulates the appetite but can also weaken your resolve not to over-indulge.

Fattening nibbles and party food are in plentiful supply right now and they can wreak havoc with your good intentions. The key here is preparation. If you know you're going to a party straight after work, have a small snack like a yoghurt or a healthy sandwich before you go, so you don't arrive hungry.

After making sure a family member can keep an eye on the turkey cooking in the oven, go for a short, invigorating walk instead of waiting around the kitchen where mouth-watering smells can soon set you snacking.

Substitute sausage meat stuffing with a delicious chestnut or fruit-based version. Cut your potatoes bigger for roasting as larger ones absorb less fat. When you finally sit down to eat your serving of turkey, remove the skin.

Pour the turkey juices into a jug and scoop off the fat after it has risen to the surface. Make bread sauce with skimmed milk and add a garlic clove for extra flavor.

After a big meal, another brisk walk can really aid digestion and help you feel refreshed. Ask the rest of your family to join you.

We know that you've made a huge effort through the year to lose weight with a balanced, nutritious diet and regular exercise. With a modicum of planning, the holidays needn't be a detour from the road to better health and a greater sense of well being.

Everyone at Insulite Laboratories wishes you a happy and healthy holiday season.

“No matter who you are, no matter what you do, you absolutely, positively do have the power to change.”

- Bill Phillips

The possibilities are limitless with a little determination.


Intelligence Report

Victims of the hormonal imbalance called Polycystic Ovarian Syndrome (PCOS) run a greater risk of developing a condition called sleep apnea. They also have an increased likelihood of developing Pre-Diabetes.

Sleep apnea is characterized by brief periods when breathing stops during sleep, increasing the risk of a stroke. Older overweight men are also more likely than their slimmer counterparts to develop the condition, which is often accompanied by loud snoring.

Obesity can be an underlying cause of both PCOS and sleep apnea. Weight loss via a balanced, nutritious diet and regular exercise is recommended by doctors as a way of reversing both disorders.

Sleep apnea stems from an obstructed airway when the throat muscles and tongue relax too much and may become enlarged or misshapen. As a result, the air passage is narrowed during sleep. This upsets the balance of oxygen and carbon dioxide in the blood stream. The brain senses a reduction in oxygen and increase in carbon dioxide before sending a signal to resume breathing. The person wakes up in response to the breathing arousal signal from the brain.

The muscles of the tongue and throat awaken to enlarge the airway and allow carbon dioxide to escape and oxygen to enter. The waking episodes are necessary to restart breathing (and keep the person alive) but they prevent the individual from getting high-quality sleep. Victims wake up frequently to restart breathing but often remember little or nothing of being awake.

PCOS, which is a leading cause of female infertility, and sleep apnea can both be linked to reversible Insulin Resistance, which creates an imbalance of glucose and insulin levels in the blood stream. If left unchecked, Insulin Resistance may lead to obesity which, in turn, can be a precursor to other serious conditions like the cluster of cardiovascular diseases called Metabolic Syndrome (Syndrome X).

Now, researchers think that sleep apnea and PCOS can increase the risk of a woman developing Pre-Diabetes, a condition diagnosed when a person's blood sugar is higher than normal but not yet in the Type 2 Diabetes range. Although reversible, Pre-Diabetes, if neglected, may lead to Type 2 Diabetes, a disorder that can only be managed for the rest of a person's life and may require daily injections of insulin.

A new study by the University of Chicago sought to determine the links between PCOS and three factors (1).

The first was hyperinsulinemia, a Pre-Diabetes condition in which the blood sugar control system does not work properly. The second factor was Body Mass Index (BMI), which is calculated by dividing weight in kilograms by the square of height in metres - a BMI of over 25 is classed as overweight, while more than 30 is regarded as obese. And the third factor was the risk of sleep apnea among women with PCOS.

The researchers screened 40 women with PCOS through a survey that asked about snoring, daytime sleepiness, hypertension (high blood pressure) and BMI. From the answers, they found that 75% of the women were at high risk for sleep apnea. Additionally, the researchers discovered that the high risk women had increased insulin levels combined with various degrees of obesity, both of which are classic symptoms of Insulin Resistance and Pre-Diabetes.

Pulmonolgist Dr. Esra Tasali, lead author of the Chicago survey, said: "Sleep apnea appears to increase the incidence of hyperinsulinemia in women with PCOS. These findings indicate that women with PCOS who suffer from sleep apnea should be closely monitored for the development of Diabetes."

All Insulin Resistance-related disorders are an increased factor for Cardiovascular Disease, which can lead to a heart attack or stroke.

(1)PCOS and Sleep Apnea,

Click here to learn about a system that helps reverse Insulin Resistance and PCOS.


New Research


Alzheimer's disease could be a Diabetes-like illness, according to a new study which has found that insulin declines as mental impairment advances (1).

"Insulin disappears early and dramatically in Alzheimer's disease," said senior researcher Suzanne de la Monte, a neuropathologist at Rhode Island Hospital and a professor of pathology at Brown University Medical School.

"And many of the unexplained features of Alzheimer's, such as cell death, appear to be linked to abnormalities in insulin signaling. This demonstrates that the disease is most likely a neuroendocrine disorder, or another type of Diabetes.

"It ties several concepts together and demonstrates that Alzheimer's Disease is quite possibly a Type 3 Diabetes," she added.

Another expert believes declining insulin levels may be an important feature of Alzheimer's but are not the whole story.

"There is now increasing evidence primarily from observational studies that Diabetes, its predecessor Metabolic Syndrome and Insulin Resistance are implicated in increasing risk for Alzheimer's disease," said Dr. Hugh C. Hendrie, a professor of psychiatry and co-director of the Center for Alzheimer's Disease and Related Neuropsychiatric Disorders at Indiana University's Center for Aging Research.

"There are many other factors also implicated in Alzheimer's, such as hypertension and inflammation, so I think it's a bit of a stretch at the moment to describe Alzheimer's disease as an endocrinological disorder like Diabetes," added Dr. Hendrie.

The Brown University team lead by Dr. de la Monte found that low levels of acetylcholine -- a hallmark of Alzheimer's -- are directly linked to the loss of insulin in the brain. Researchers autopsied the brain tissue of 45 patients diagnosed with different degrees of Alzheimer's called "Braak Stages" and compared those tissues to samples taken from individuals with no history of the disease.

The team analyzed insulin and insulin receptor function in the frontal cortex of the brain, a major area affected by Alzheimer's. They found that, as the severity of Alzheimer's increased, the levels of insulin receptors and the brain's ability to respond to insulin decreased.

"In the most advanced stage of Alzheimer's, insulin receptors were nearly 80% lower than in a normal brain," said Dr. de la Monte.

The researchers found two abnormalities related to insulin in Alzheimer's. First, as mentioned, levels of insulin dropped as the disease progressed. Second, insulin and its related protein, called insulin-related growth factor -I, lose the ability to bind to cell receptors. This creates a resistance to insulin growth factors, causing the cells to malfunction and die.

Dr. de la Monte said: "We're able to show that insulin impairment happens early in the disease. We're able to show it's linked to major neurotransmitters responsible for cognition. We're able to show it's linked to poor energy metabolism, and it's linked to abnormalities that contribute to the tangles characteristic of advanced Alzheimer's disease."

Dementia has been connected with Insulin Resistance, which lowers the number of insulin receptor sites on the cell walls and prevents the efficient conversion of glucose into energy. If left unchecked, the resulting imbalance and excess of glucose and insulin can lead to obesity.

This condition, in turn, may result in the onset of a number of potentially dangerous disorders, including the cluster of cardiovascular diseases called Metabolic Syndrome or Syndrome X, which, if neglected can impair blood flow to the brain as well as increasing the risk of a heart attack or stroke. The latter, in particular, can result in neurological damage.

(1) Impaired insulin and insulin-like growth factor expression and signaling mechanisms of Alzheimer's Disease - is this Type 3 Diabetes?,
P63-80, Journal of Alzheimer's Disease, Vol 7, Number 1, 3/3/05

  Weight Loss: Myth or Fact?
Myth: Sit-Ups Help You Lose Weight.

Fact: The media's incessant focus on "perfect" bodies via coverage of the worlds of Hollywood and modeling have helped to make many men and women ultra-conscious of their body image.

As a result, some people are always looking to target specific areas of their bodies with exercises. They often believe, for example, that regular sit-ups will lead to a picture-perfect, washboard stomach as well as weight loss.

But there is no such thing as spot reduction, according to experts. Sit-ups and crunches can strengthen your abs but they can't get rid of fat.

"Only regular exercise training — aerobic and strength — and a sensible diet can eliminate excess body fat," says Cedric Bryant, Ph.D., chief exercise physiologist at the American Council on Exercise.

Dr Mary Shackelton - Medical Director for Insulite Laboratories
Q. Can Metabolic Syndrome damage your liver as well as your heart?

A. Yes, it can. Until now, the risks associated with having Metabolic Syndrome have focused on cardiovascular symptoms: high blood pressure, high cholesterol, high CRP (C reactive protein) and high homocysteine. But research conducted in 2005 has confirmed that there may be another danger associated with Metabolic Syndrome – a risk of complications in liver function.

Non Alcoholic Fatty Liver Disease (NAFLD) is a disorder primarily associated with Insulin Resistance-linked obesity and Metabolic Syndrome. It can be considered a hepatic or liver manifestation of the syndrome and is diagnosed via a blood test which shows elevated concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALK) - all factors that can be predictive of Metabolic Syndrome.

This disease progression occurs when abnormal fat metabolism leads to an accumulation of triglycerides in the liver, causing an increase in liver enzymes. Additionally, several chemical messengers made by the fat cells contribute to systemic inflammation which may be limited to the liver or expressed throughout the body. This inflammation can directly affect the liver by causing fibrosis and the risk of advanced liver disease.

The way to reverse NAFLD is to lose weight, gain control of insulin sensitivity and reduce inflammation.

Further reading:

Bugianesi E, McCullough AJ, Marchesini G.
Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005 Nov; 42 (5):987-1000.

Hanley AJ, Williams K, Festa A, Wagenknecht LE, D'Agostino RB Jr, Haffner SM. Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study. Diabetes: 2005 Nov: 54 (11): 3140-7.

Gasbarrini G, Vero V, Miele L, Forgione A, Hernandez AP, Greco AV, Gasbarrini A, Grieco A. Nonalcoholic fatty liver disease: defining a common problem. Eur Rev Med Pharmacol Sci. 2005 Sept-Oct: 9(5): 253-9.

Have You Been Diagnosed with Pre-Diabetes?

If You Have, We’re Glad That You Have Found Us.

We’re Here to Support You.

PreD ProductInsulite Laboratories is committed to reversing Pre-Diabetes by giving you a better understanding of your condition and its underlying cause, Insulin Resistance.

Supporting you and conveying as much information as possible is central to our philosophy.

If left unchecked, Pre-Diabetes can lead to Type 2 Diabetes, which can only be managed for the rest of a person's life and may require daily injections of insulin. Like all Insulin Resistance-linked conditions, Pre-Diabetes can be an increased risk factor for Cardiovascular Disease leading to a heart attack or stoke.

So we are pleased to announce the imminent launch of the Insulite Pre-Diabetes System, which has been scientifically-formulated to help reverse Insulin Resistance and Pre-Diabetes.

It contains a specialized product called Pre-DiabetX which directly impacts the level of blood glucose.

Check next month's edition of Viewpoints for more details.

Weight and Infertility


Women who are obese are likely to face problems becoming pregnant through fertility treatment.

Researchers in Australia studied 3,500 women who received treatment and found very obese women had a 60% lower chance of getting pregnant than those of moderate weight (1).

Underweight women often also fail to become pregnant through assisted reproduction.

Many obese women have problems conceiving naturally. But research by the University of Adelaide found they can continue to have trouble becoming pregnant when they receive treatment such as in-vitro fertilization.

Women in the study were classed using their body mass index (BMI), which is calculated by dividing weight in kilograms by the square of height in meters. A healthy rating is 20-25. A BMI of over 25 is classed as overweight, while 30 or more is regarded as obese.

The study found that women with a BMI of over 35 had a 30% chance of becoming pregnant through fertility treatment, compared to 48% for those with a moderate rating of between 20 and 25. Underweight women had a 45% chance of success.

Researchers looked at a cross section of women receiving fertility treatment between 1989 and 1998. They already knew that obesity can lead to menstrual and ovulation problems but found that being overweight can also disturb the lining of the uterus and result in a failed implantation of the embryo.

Dr Michael Davies, one of the study authors, said of obese women: "The distinctive characteristic is that, when they come for treatment, they have conspicuous reproductive problems. There is really a quite strong effect of obesity which affects the effectiveness of treatment."

(1) Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study;, British Medical Journal, November 2000: P 1320-1321

“It is exercise alone that supports the spirits and keeps the mind in vigor.”
  - Marcus Tullius Cicero
It's as true today as it was in Ancient Rome.


Red Wine


Eat, drink and be merry over the holidays, knowing that red wine in moderation is doing you some good.

The health difference between red and white wine lies in their respective grape skins. The color of red wine is produced by a substance called anthocyanin, which is also responsible for the coloring of black olives, strawberries, cherries and raspberries.

Anthocyanin is one of the four main groups of chemicals that together are called flavanoids. Research has shown many potential medical uses for flavanoids, ranging from the regulation of cell growth to functioning as antioxidants, reducing inflammation of the arteries and preventing blood clots.

Red wine also contains polyphenrols which reduce the amount of bad LDL cholesterol in the arteries and increase the levels of protective HDL cholesterol. The antioxidants in red wine - tannin and resveratrol - can help to guard against cancer as well as slowing tumor growth.

Red wine could also hold the secret to repairing joint damage caused by osteoarthritis. Scientists have found that resveratrol appears to halt the damage done to cartilage - the gristle-like substance that covers the ends of bones in a joint - and speeds up recovery.

During laboratory experiments, tissue was taken from patients undergoing knee replacement surgery and cells were exposed to small doses of resveratrol. The results, presented at a recent American College Of Rheumatology meeting in San Diego, showed the wine chemical protected cells in the knee joint against further damage.

Osteoarthritis develops when cartilage becomes roughened and thin. In a healthy joint, the cartilage acts as a cushion, spreading forces evenly when pressure is applied. Its smooth, slippery surface also allows the bones to move freely.

The cartilage stays slippery and smooth thanks to a thick fluid - called synovial fluid - produced by a membrane that surrounds the joint. But if the cartilage breaks down, usually through wear and tear, the bone underneath starts to thicken and the joint becomes inflamed. In severe cases, the bones grind together, which can be extremely painful.

Treatments range from painkilling creams and pills to steroid injections, designed to curb the swelling inside the joint. But many people have to have replacement joints.

The latest findings hint at a possible new treatment based on red wine, although the research is still at a very early stage. A team of scientists from the New York University School Of Medicine decided to see if the anti-oxidant resveratrol would prevent what is called 'oxidative injury'.

This is where oxygen-rich particles cause severe damage to body cells through oxidation, a process some scientists compare to the way rust rots a car. They chose the wine compound because a wide range of studies suggests it has powerful healing properties.

Tiny samples of cartilage taken from damaged knee joints were combined with red wine's resveratrol. The results showed it slashed production of chemicals that cause inflammation in the joints by between 50-90% It also stimulated production of key proteins that make up an important part of the connective tissue in the joints.

So it seem that red wine wins hands when it comes to health. Clinical trials have shown that the protective activity of flavanoid-reduced white wine was only about 20% of the red variety. Sadly, the antioxidant supplements of white wine such as vitamin E do not reduce coronary heart disease mortality, no matter how refreshing a good, chilled Chardonnay may taste. 

Smoked SalmonSnacks abound at this time of year but they don't all have to be diet-wrecking. Why not try this healthy smoked salmon spread, which is delicious on crackers? Or serve it with Belgian endive leaves. Or cut whole-wheat pita bread into triangles, bake until crisp, then spread the salmon and sprinkle with kosher salt.


  • 6 oz smoked salmon, chopped

  • 6 oz low-fat cream cheese, 1/4 cup nonfat sour cream

  • 1 tbs freshly squeezed lemon juice

  • 2 tbs chopped fresh dill

  • 1 scallion, white part only, minced

  • 1/4 teaspoon freshly ground black pepper
In a food processor or mixer at slow speed, blend the salmon, cream cheese, sour cream and lemon juice until fairly smooth.

Mix in the dill, scallion and pepper.

Cover and refrigerate up to 3 days.

Recipe makes about 1-1/2 cups.

Insulite Laboratories is Here for You
You are well on the way to reversing your Insulin Resistance and preventing its related conditions such as PCOS (Polycystic Ovarian Syndrome), Metabolic Syndrome (Syndrome X) and Pre-Diabetes. You are also taking important steps to achieving your desired weight loss goal and the healthy lifestyle you deserve.

Remember that persistence is crucial.

We at Insulite Laboratories are committed to your success and your well being. We're here to help you.

Please contact us with any questions or to order the Insulite System, Insulite PCOS System, or the new  Insulite MetaX System at

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DISCLAIMER: The information contained in this newsletter is for the sole purpose of being informative. This information is not and should not be used or relied upon as medical advice. Always seek the advice of your physician, nurse or other qualified health care provider before you undergo any treatment, take any medication, supplements or other nutritional support, or for answers to any questions you may have regarding a medical condition.

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