Insulite Laboratories
Systems That Restore Health
August 2007

Dr. Heather DeLuca

Dr. Heather DeLuca
of Our Medical
& Advisory Team

Welcome to the 41st edition of Viewpoints, our monthly e-newsletter. Click on In This Issue headlines to read individual articles.


 Researcher looking at specimen slide.
Diabetes damages a man's sperm and may reduce his fertility, according to a new report.

Tests showed DNA in sperm from Diabetic men had more signs of damage than in men without the condition. Defective sperm DNA is one cause of male infertility, failure to become pregnant and miscarriage.

The British research team which made the findings said their report was worrying, given rapidly rising rates of Diabetes throughout the world.

Their study of 56 sperm samples is the first to compare the quality of DNA in sperm from men with and without Diabetes. Around 52% of the DNA in the sperm cells was fragmented in Diabetic men, compared with 32% in men without the condition. The study also found a higher rate of deletions of DNA in the mitochondria - tiny, energy-generating compartments found within cells.

Semen volume was also significantly less in Diabetic men, though there were no significant differences in sperm concentration or the ability of the sperm to move.

Although the men in the study had Type 1 Diabetes - where the body does not produce insulin - the researchers have found the same DNA damage in sperm from men with Type 2 Diabetes - the more common form of the disease where the body does not produce enough insulin or does not respond properly to it.

Diet and obesity are known to be key factors in the increase of Type 2 Diabetes, which normally starts in adulthood. But the incidence of Type 1 Diabetes, which is usually diagnosed in childhood or adolescence, is also increasing in young people.

Study author Dr Ishola Agbaje, a research fellow in the Reproductive Medicine Research Group at Queen's University, Belfast, said: "Diabetes will affect many more men prior to and during their reproductive years."

Obesity is often a key factor in the onset of Diabetes. Regular exercise when combined with a balanced, nutritious diet can help reverse an underlying cause of obesity, namely the imbalance of blood glucose and insulin called Insulin Resistance. By reversing Insulin Resistance, you can facilitate weight loss.

Full-blown Type 2 Diabetes is irreversible. But before the onset of this condition, most people develop reversible Pre-Diabetes, a condition in which blood sugar levels are elevated beyond normal but not high enough for a diagnosis of Type 2 Diabetes. Left unchecked, Pre-Diabetes may lead to the Type 2 variety, which can only be managed for the rest of a person's life. Many Diabetics require daily injections of insulin.

Type 2 Diabetes severely increases the risk of blindness, amputation and kidney disease, as well as a heart attack or stroke. Some 90% of people with Type 2 also suffer from excess weight or obesity.

 Close-up of woman with head tilted back and to the side.
The carotid artery located in the neck is thicker in women with PCOS, a new study has found.

The report suggests PCOS sufferers are at higher risk for developing cardiovascular disease leading to a heart attack or stroke as result of having a thicker carotid artery.

The increased thickness may be as a result of women with PCOS having higher than normal androgen levels.

Researchers recommended that PCOS sufferers should be treated to reduce their androgen levels and make appropriate life-style modifications to prevent the development of heart disease. The changes include a balanced, nutrutious diet and regular exercise to lose excess weight.

Although lean women are also prone to PCOS, obesity is often an underlying cause of the disease - a leading source of menstrual irregularity and infertility, as well skin conditions like acne and brown patches, excess facial and body hair, female baldness and reduced sex drive.

A team in Madrid, Spain, measured carotid artery thickness using ultra-sonography in 12 women with high levels of androgens - a key feature of PCOS.

"The women in our study had much thicker carotid arteries compared with the standards for healthy women," explained Dr. Jose I. Botella-Carretero, one of the study's authors.

"Previous research has shown that an increase in carotid artery thickness is a cardiovascular risk factor and has also been related to Insulin Resistance," he added.

 Dr. Mary Shackelton
Insulin is, of course, a major player in the development and progression of Insulin Resistance. But also strongly linked with the latter condition is visceral adiposity.

This term refers to a storage of fat cells called adipocytes. When large numbers of adipocytes are present, they form a tissue that acts like it is a separate and functional organ in the body. The net effect is that the adipocytes affect insulin signaling and the ability of insulin to effectively lower glucose levels in the blood.

There are two kids of fat tissue, White Fat and Brown Fat. Brown adipose tissue has a higher fat content and has the unique ability to generate heat. White Fat comprises the majority of fat that adults have and is non-heat generating.

Recent research confirms that the location of stored fat impacts the progression of Metabolic Syndrome - the cluster of increased risk factors for heart disease than can lead to a heart attack or a stroke. (1)

Fat deposits on thighs and upper arms have a different impact metabolically on the body than fat stored in the abdomen. Central adiposity is blamed for being the "headquarters" or "traffic controllers" of Metabolic Syndrome. It is likely that fat stored in the abdomen plays a role in the complex interplay involving hormones, metabolism and neural signaling that can trigger the development of metabolic degeneration leading to heart disease.

The more fat a person stores in their midrift, the more abnormal insulin signaling, abnormal glucose regulation and greater metabolic stress the individual experiences.

The waist hip ratio (WHR) often used to assess risk for cardiovascular disease is higher for people who store their fat in their abdomen and increases their risk of cardiovascular disease. Therefore those who have larger middles have a higher WHR or an "apple shaped body" and have increased risk for a heart attack or stroke.

(1)  Eriksson JW.Metabolic stress in insulin's target cells leads to ROS accumulation - A hypothetical common pathway causing insulin resistance. FEBS Lett. 2007 Jun 27.

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 Man bent over in a painful stretch.
Sticking to the right routine both before and after exercise is important if you want to avoid possible trouble that can stem from tight muscles, soreness and pain.

Knowing how to warm up and then cool down afterwards is the best way to avoid problems that can affect your whole fitness regime. Last month we featured some exercises that showed how to stretch safely and this month we have some more for you.

Stretches ankles

  1. Stand and hold onto something for balance
  2. Lift right foot and rotate foot and ankle 8 to 10 times clockwise, then 8 to 10 times counter-clockwise.
  3. Repeat on other side (Note: can also be done sitting)
Stretches calf

  1. Stand a little way from wall and lean on it with forearms, head resting on hands
  2. Place right foot in front of you, leg bent, left leg straight behind you
  3. Slowly move hips forward until you feel stretch in calf of left leg
  4. Keep left heel flat and toes pointed straight ahead
  5. Hold easy stretch 10 to 20 seconds
  6. Do not bounce
  7. Repeat on other side
  8. Do not hold breath
Stretches front on thigh (quadriceps)

  1. Stand a little a way from wall and place left hand on wall for support
  2. Standing straight, grasp top of left foot with right hand
  3. Pull heel toward buttock
  4. hold 10 to 20 sec
  5. Repeat on other side
Relaxes hamstrings, stretches calves, achilles, and ankles

  1. Stand with feet shoulder-width apart
  2. Keep heels flat, toes pointed straight ahead
  3. Assume bent knee position (quarter squat)
  4. Hold 30 sec
Stretches inner thigh, groin

  1. Stand with feet pointed straight ahead, a little more than shoulder-width apart
  2. Bend right knee slightly and move left hip downward toward right knee
  3. Hold 10 to 15 seconds
  4. Repeat on other side
  5. If necessary, hold on to something (chair, etc.) for balance
Stretches side of hip, hamstrings

  1. Sit on floor with right leg straight out in front
  2. Bend left leg, cross left foot over, place outside right knee
  3. Pull left knee across body toward opposite shoulder
  4. Hold 10 to 20 seconds
  5. Repeat on other side
  6. Breathe easily
Stretches lower back, side of hip, and neck

  1. Sit on floor with left leg straight out in front
  2. Bend right leg, cross right foot over, place outside left knee
  3. Bend left elbow and rest it outside right knee
  4. Place right hand behind hips on floor
  5. Turn head over right shoulder, rotate upper body right
  6. Hold 10 to 15 seconds
  7. Repeat on other side
  8. Breathe in slowly
Stretches back of leg and lower back

  1. Sit on floor, legs straight out at sides
  2. Bend left leg in at knee
  3. Slowly bend forward from hips toward foot of straight leg until you feel slight stretch
  4. Do no dip head forward at start of stretch
  5. Hold this developmental stretch 10 to 20 seconds
  6. Repeat on other side
  7. Foot of straight leg upright, ankles and toes relaxed
  8. Use a towel if you cannot easily reach your feet
Stretches shoulders, arms, hands, feet and ankles

  1. Lie on floor, extend arms overhead, keep legs straight
  2. Reach arms and legs in opposite directions
  3. Stretch 5 sec, relax
Insulite Laboratories Systems
New evidence of the growing obesity epidemic and its related diseases seems to feature in the media every month.

But so, too, does encouraging news that the health problems associated with weight gain can be tackled with a little determination.

Regular exercise is vital. A recent survey, for example, by the Brigham and Women's Hospital - a Harvard Medical School teaching affiliate - reported that women over the age of 45, from the skinny to the obese, improved their cholesterol levels and other cardiovascular risk factors simply by going for five brisk, 30-minute walks each week.

We can't over-emphasis the value of regular exercise. That's why it is such a part of our commitment to helping you every step of the way towards weight loss and better health.

Quick Links
"I would like to tell you how happy I am with the results I have seen in myself for the past three months since I started the Insulite System.

"I am starting my fourth month and have now lost 23 lbs. and 3-5 inches. Plus, for the first time in my life I have had my period for two consecutive months and they didn't last as long as usual. Of course, my acne and facial hair have lessened also."

Amanda Ward
Las Vegas, NV
Have You Been Diagnosed with Diabetes?

If You Have, We're Here to Help You Restore Your Health

Insulite Laboratories is committed to giving you a better understanding of adult Type 1 Diabetes and both Insulin-Dependent and Non-Insulin-Dependent Type 2 Diabetes.

A common underlying cause of all these Diabetic conditions is Insulin Resistance. So we are very pleased to announce the imminent launch of the Insulite Diabetes Advanced Management System, which has been scientifically-formulated to help reverse Insulin Resistance.

Left unchecked, this latter condition can keep increasing your need for insulin and raise the risk of you eventually developing Diabetic complications like blindness, kidney disease and the need for amputation.

The Insulite Diabetes Advanced Management System is designed to help you either avoid developing these complications completely or delay the onset of those afflictions for many years while you enjoy better health in the meantime.

Although there is no cure for Diabetes, the Insulite System is designed to increase insulin sensitivity and thus reduce your dependence upon insulin. As a result, you may experience the best sense of well being that you have known since being first diagnosed as a Diabetic.

The multi-level Insulite System includes a carefully-designed combination of disease specific nutracueticals which are primarily designed to increase the number of insulin receptor sites on the surface of each cell.

As a result, cells can absorb blood glucose through the receptor sites more efficiently for conversion to energy. The resulting increase in insulin sensitivity can have a hugely beneficial impact on a Diabetic's health.

Keep reading our Viewpoints newsletter for more details about The Insulite Diabetes Advanced Management System.