Insulite Laboratories
Systems That Restore Health
April 2007

Welcome to the 37th edition of Viewpoints, our monthly e-newsletter. Click on In This Issue headlines to read individual articles.


 Asthma Inhaler
People who suffer from excess weight or obesity have a staggering 50% higher risk of developing asthma than those of a normal, healthy weight, a new study.

Evidence of the increased risk emerged after researchers reviewed seven medical studies involving over 330,000 adult patients, the American Journal of Respiratory and Critical Care Medicine reported.

Asthma affects the small tubes, or airways, that carry air in and out of the lungs. When something triggers asthma, the muscle around the walls of the airways tightens and the airways narrow.

The lining of the airways becomes inflamed and starts to swell, often producing mucus or phlegm.These reactions cause the airways to become irritated, leading to the symptoms of asthma, such as wheezing, shortness of breath and a tight chest.

The study, by a joint team from the US National Jewish Medical and Research Center and the University of Colorado, used accepted guidelines to classify normal weight as someone with a body mass index (BMI) below 25, overweight as over 25 but below 30 and obese as 30 and above.

The statistical analysis showed that for every normal weight person with asthma, there were 1.5 people with asthma who were overweight or obese. The risk of having asthma for those who were obese was twice that of someone of normal weight.

Researchers could not pinpoint what caused the increased risk of asthma. But obesity causes impairments in lung function, such as a reduction in lung volume and an increase in the amount of oxygen used during breathing.

These on their own would not, however, be enough to induce the condition. But lead researcher Dr Rand Sutherland said: "If significant weight loss could be achieved in the population of overweight and obese individuals, it could be estimated that the number of new asthma cases could fall significantly."

Previous studies have shown that losing weight and becoming fitter via a balanced, nutritious diet and regular exercise can help in both managing asthma and improving lung function.

An underlying cause of obesity is often the imbalance of blood glucose and insulin called Insulin Resistance. By reversing Insulin Resistance, you can facilitate weight loss.

 Unhappy couple
Doctors are stressing the need to reverse Pre-Diabetes is growing ever more urgent after the disclosure that more than half of the 18 million Americans who currently suffer from full-blown irreversible Type 2 Diabetes have at least one of numerous other major illnesses. These conditions can range from failing eyesight and heart disease to erectile dysfunction and an increased risk of kidney disease and amputation.

A new report, The State of Diabetes Complications in America, from The American Association of Clinical Endocrinologists shows that nearly 60% of people with Diabetes have complications caused by long-term failure to control the high blood-sugar levels tied to the disease.(1)

Many Type 2 Diabetics require daily injections of insulin. But before full-blown Type 2 Diabetes takes hold, most people experience Pre-Diabetes, a condition in which blood sugar levels are elevated beyond normal but not high enough for a diagnosis of Type 2. Left unchecked, Pre-Diabetes may lead to the Type 2 variety. But Pre-Diabetes can be reversed before it becomes Type 2 by reversing Insulin Resistance, an imbalance of blood glucose and insulin that can be an underlying cause of Diabetes.

Most of the complications from Type 2 Diabetes could have been avoided with early diagnosis and aggressive treatment, says Daniel Einhorn, a board member of the Endocrinologists Association which produced the report. High levels of sugar in the blood can damage veins, causing heart disease and stroke, vision loss, kidney disease and loss of circulation to the legs and feet that may result in amputation, he added.

A separate report in the April issue of Archives of Neurology adds to studies that have linked Diabetes to a heightened risk for cognitive impairment, marked by problems in learning and thinking.

Dr. Einhorn says studies show that intense, early treatment with improved diet, daily exercise and medications when needed can lower blood-sugar levels and prevent or at least delay complications.

But "we are failing in the primary mission of preventing complications," he says. "The problem is that people don't recognize Diabetes early enough, so, by the time of diagnosis, about half of people with Diabetes already have a complication that took years to develop."

Based on data from national surveys, the report is the first to combine economic and health data on Type 2 Diabetes complications.

It estimates the cost of treating complications at $22.9 billion in 2006, says University of Chicago health economist Willard Manning, who contributed to the analysis. He says people with Diabetic complications face health costs three times those of non-Diabetics and can expect to spend an average $1,600 per year in out-of-pocket expenses for care that averages nearly $10,000 a year, most of it paid by insurance.

The endocrinologists' report, which was paid for by drug manufacturer GlaxoSmithKline, notes that the prevalence of complications is greater in black people (about 59%) than whites (about 55%), and highest in Hispanics (about 68%).

Dr. Einhorn says Diabetes, like high blood pressure or high cholesterol, is easy to ignore until it has already caused damage. "There is a huge cost to denial of this disease," he added.


An estimated 57.9% of people with Diabetes have one or more complications as a result of the disease:
  • One: 33.3%
  • Two: 10.3%
  • Three: 6.7%
  • Four or more: 7.6%
Most common complications in people with Type 2 Diabetes:
  • Chronic kidney disease: 27.8%
  • Foot problems: 22.9%
  • Eye damage: 18.9%
  • Heart attack: 9.8%
  • Chest pain: 9.5%
  • Coronary heart disease: 9.1%
  • Congestive heart failure: 7.9%
  • Stroke: 6.6%
(1) The State of Diabetes Complications in America.
PRNewswire, Seattle, WA, April 10, 2007

 Dr. Mary Shackelton
Yes, they do. An April 2007 study confirms that women with PCOS store their fat differently than women who are overweight but who do not have the condition. (1)

PCOS patients tend to store their weight in the middle of their abdomen, not in the lower abdomen. The place where the excess fat is stored is a predictor of how a woman is responding to her insulin.

The new report confirms that women who store their fat in the middle of their abdomen have more insulin (which signals more fat storage) and respond less well to the insulin that they are producing.

To stop this vicious cycle, we know that women with PCOS need to curtail their requirements for insulin by reducing carbohydrate intake. By improving response to insulin, less insulin is produced and women can begin to shed weight.

Weight loss is important for many reasons for women with PCOS. But this study confirms that losing weight in the central abdominal area decreases the likelihood of being Insulin Resistant and improves the likelihood of being able to reverse PCOS.

(1)  Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G., Abdominal Fat Quantity and Distribution in women with PCOS and the Extent of of Its Relation to Insulin Resistance.
J Clin Endocrinol Metab. 2007 Apr 3, PMID: 17405838

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 Woman lifting weights
No part of your body is spared the effects of ageing, which is why it's best to exercise all of it, no matter how old you are.

Aerobic capacity and muscle strength will decline as the years pass. But regular training can provide the right exercise to slow the process dramatically, enabling you to manage your weight, enjoy good health and count on lots of energy for the foreseeable future.

Even people in their 80s can benefit from regular exercise such as a swimming and walking regime tailored to their age and physical condition.

Supplying oxygen to the muscles as quickly as possible is a crucial factor in staying strong and keeping fit as you age. Oxygen is part of the fuel that allows muscle tissue to produce mechanical energy by contracting. Blood glucose is the other necessary fuel.

When you begin training exercises such as lifting hand weights, the body's demand for oxygen increases because muscles require more oxygen for fuel.

The body's capacity to use oxygen is actually measurable. It's called "oxygen uptake" and is designated VO2, which registers the liters of gas absorbed per minute through breathing. When people train, their V02 goes up; if they become sedentary, it goes down.

Training not only raises the limit of maximum oxygen uptake but it also dramatically increases the level of exertion a person can sustain for long periods. This is why a normally sedentary person struggles to keep up with a fit friend even during simple exercise such as walking.

A huge benefit of training can be the maintenance of the heart's ability to move oxygen-rich blood around the body and reduce the risk of developing the cluster of increased risks for cardiovascular disease called Metabolic Syndrome (Syndrome X).

Muscle strength declines 10-15% per decade, starting at about age 30. This is because there is actual loss of muscle fibers and the nerves that drive them. The decline is also due to some fibers that used to generate brief bursts of power becoming transformed to long-acting endurance fibers – a change that reduces strength overall.

By age 70, a person is only half as strong as he or she was in their youth, though maintaining a training program throughout the decades can help ensure that strength and fitness remains good for whatever age a person is.

It's never too late to start a training program in order to lose weight and keep fit. However, you should always consult your doctor first before beginning a strenuous new exercise regime.

Local gyms are usually happy to offer free advice about the kind of strength training that suits an individual's needs at any age. By staying strong, you'll enjoy a great sense of well being.
Insulite Laboratories Systems
We at Insulite Laboratories are very concerned that excess weight and obesity continue to take a growing toll on people's health.

The latest figures show that around two-thirds of American adults, some 136 million men and women, are now overweight or obese.

Other research has revealed that overweight Americans are sicker later in life and die earlier than people of normal, healthy weight.

One study concluded, for example, that obese women experience an average of three more years of ill health than normal-weight females.

Insulite Laboratories believes that a balanced, nutritious diet and regular exercise are the keys to losing weight. We are dedicated to helping you in any way we can to enjoy better health.

Quick Links
"I found the website for Insulite Labs one afternoon while researching PCOS. I had been diagnosed with it about two years before and I had gotten married in 2005. My husband and I wanted to start a family but I was very reluctant to take drugs such as Metformin or any others. The side effects did not sound appealing – I have enough problems!

"I ordered the Insulite PCOS system in July. My cycle returned to normal from August to December. I lost 15 lbs during that time and I have to admit I wasn't even the most dedicated follower. Then in January, the pills appeared to quit working. I missed my period that month and the next three. I was frustrated. I had put the weight back on, was feeling tired again, and wasn't very happy about it. Until the beginning of April when something made me start thinking: what if the pills did work? What if they worked better than even I had hoped?

"I took a home pregnancy test, followed by a visit to my doctor. I was four months pregnant!!! What a delightful, wonderful surprise! That very first afternoon, I heard the baby's heartbeat and was sent for an ultrasound two days later to determine the due date. The ultrasound was amazing – I am 16 weeks pregnant!

"Thank you for your wonderful product and the joy it is going to bring to our lives!!"


Have You Been Diagnosed with PCOS?

If You Have, We're Here to Help You Restore Your Health

Insulite Laboratories is committed to giving you a better understanding of Polycystic Ovarian Syndrome (PCOS) and a common underlying cause of the condition, namely Insulin Resistance-linked excess weight or obesity.

So we are very pleased to offer the Insulite PCOS System, which has been scientifically-formulated to help reverse Insulin Resistance, an imbalance of blood glucose and insulin.

PCOS is a major cause of female infertility, as well as irregular periods and excessive bleeding, obesity, skin conditions like acne and brown patches, excess body hair, female baldness and reduced sex drive.

The Insulite PCOS System includes a scientifically-designed combination of nutrients which are primarily designed to increase the number of insulin receptors on the surface of each cell.

As a result, cells can absorb blood glucose through the receptor sites more efficiently for conversion to energy, thereby reducing levels of circulating glucose. A decrease in elevated blood glucose lowers the secretion of insulin, which are both major underlying causes of excess weight gain and obesity.

When insulin and glucose are in balance, weight loss is facilitated and a related disease like PCOS can be reversed.

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